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2020 Agenda
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Friday, April 3

Event

Location

7:00 am - 6:30 pm

Registration Desk Hours

International Foyer

8:30 am - 11:00 am

APSA Business Meeting

Rouge

10:00 am - 12:00 pm Networking Workshop for ASCI's Young Physician-Scientist Awardees  

11:00 am - 1:00 pm

APSA Session I - Disrupting Precision Medicine

International Ballroom

11:00 am - 11:30 am

APSA Speaker:

Speaker HeadshotJennifer Wargo, MD
MD Anderson Cancer Center

Dr. Wargo’s career commitment has been to advance the understanding and treatment of disease through science. With a joint appointment in Surgical Oncology and Genomic Medicine, she continues her critical research to better understand responses to therapy and develop novel strategies to combat resistance. This includes her groundbreaking recent work elucidating the role of the gut microbiome in shaping responses to immunotherapy in patients with melanoma and a clinical trial underway exploring optimal methods to manipulate the gut microbiome to enhance responses to cancer therapy.

International Ballroom

11:30 am- 12:00 pm

APSA Speaker:

Speaker HeadshotDefining the Genetic, Genomic and Cellular Architecture of Kidney Diseases
Katalin Susztak, MD PhD
Perelman School of Medicine, University of Pennsylvania

Dr. Katalin Susztak is a physician-scientist at the University of Pennsylvania. Her laboratory is interested in understanding the pathomechanism of chronic kidney disease development. Susztak has made discoveries fundamental towards defining critical genes, cell types and mechanisms of chronic kidney disease. She was instrumental in defining genetic, epigenetic transcriptional changes in diseased human kidneys. She identified novel kidney disease genes and demonstrated the contribution of Notch signaling and metabolic dysregulation in kidney disease development.

Her lab was the first to map the kidney epigenome and catalogue genotype-driven gene-expression variation (eQTL) in human kidneys. Integration of GWAS, eQTL and epigenome data has been essential to prioritize disease-causing genes and variants.

Dr. Susztak generated the first unbiased, comprehensive kidney cell-type atlas using single cell transcriptomics. She identified that specific renal endophenotypes are linked and likely caused by the dysfunction of specific cell types.

International Ballroom

12:00 pm - 1:00 pm

Break

 

1:00 pm - 3:00 pm

Poster Setup

Imperial Ballroom

1:00 pm - 6:00 pm

Plenary Session I: Disruptive Engineering in Medicine

International Ballroom

1:00 pm – 1:30 pm

Invited Speaker:

Speaker Headshot

How Mitochondria and Lysosomes cause Autoimmune Disease 
Cornelia Weyand, MD, PhD
Stanford University

Cornelia M. Weyand, M.D., Ph.D. is Professor of Medicine and Director of the Center for Translational Medicine at Stanford University School of Medicine.

Dr. Weyand is leading a research team in translational immunology supported continuously through funding from the National Institute of Health. She has a special interest in tissue-damaging immune responses in rheumatoid arthritis, atherosclerosis and large vessel vasculitis. Dr. Weyand’s research team has defined the role of T cells and dendritic cells in deviating immunity from protective to destructive and over the last decade, she has devoted special emphasis to the remodeling of the immune system with aging, how chronic disease ages the immune system, and how aged immune cells cause inflammation.

She has defined molecular defects underlying the immune abnormalities driving rheumatoid arthritis, implicating defects in mitochondrial DNA repair and intracellular protein trafficking to lysosomal surfaces. Her team has defined metabolic signatures that are linked to pathogenic behavior of T cells and macrophages, representing novel targets for immunomodulatory therapy.

International Ballroom

1:30 pm – 2:00 pm

Invited Speaker:

Speaker Headshot

Assessing Cancer Metabolism in Human Tumors in Vivo
Ralph DeBerardinis, MD, PhD
UT Southwestern

Ralph DeBerardinis studies the role of altered metabolism in pediatric inborn errors of metabolism, cancer and other diseases. He is an Investigator in the Howard Hughes Medical Institute and Professor in the Children’s Research Institute (CRI) at UT Southwestern Medical Center. Dr. DeBerardinis earned a B.S. in Biology from St. Joseph’s University and M.D. and Ph.D. degrees from the University of Pennsylvania. He then trained in Pediatrics, Medical Genetics and Clinical Biochemical Genetics at The Children’s Hospital of Philadelphia before moving to UT Southwestern. Dr. DeBerardinis is Chief of Pediatric Genetics and Metabolism at UT Southwestern, where his clinical team seeks to improve diagnostics and care of children with genetically-defined metabolic disorders. He also directs the CRI’s Genetic and Metabolic Disease Program, which performs basic and translational research to discover new aspects of metabolic disease amenable to clinical intervention. The DeBerardinis laboratory has identified many metabolic pathways that support cancer cell growth and cancer progression. Dr. DeBerardinis received an Outstanding Investigator Award from the National Cancer Institute in 2017 and the O’Donnell Award in Medicine from the Academy of Medicine, Engineering & Science of Texas in 2019.

International Ballroom

2:00 pm - 3:00 pm ASCI and AAP New Member Presentations International Ballroom
3:00 pm - 3:30 pm Break
3:30 pm - 4:00 pm ASCI / Harrington Prize Lecture International Ballroom

4:00 pm - 4:30 pm

APSA Lasker Award Winner Lecture

Speaker Headshot Max D. Cooper, MD
Emory University

International Ballroom

4:30 pm - 5:00 pm

ASCI Presidential Address

Speaker Headshot Kimryn Rathmell, MD, PhD
Vanderbilt University

International Ballroom

5:00 pm - 5:30 pm

ASCI/Stanley J. Korsmeyer Award Lecture

International Ballroom

5:45 pm - 7:00 pm

APSA-Trainee-Specific Business Meeting focusing on international training collaborations

 State

6:00 pm – 7:00 pm

ASCI President's Reception
Celebrating 5 Years of the Seldin~Smith Award

Gold Room

6:15 pm – 9:30 pm

Poster Viewing 

Imperial Ballroom

7:30 pm - 9:45 pm

ASCI Dinner and New Member Induction Ceremony

Rouge

9:00 pm – 12:00 am

APSA Welcome Reception (all attendees welcome)

Mid-America Club

Saturday, April 4

Event

Location

7:00 am - 6:30 pm

Registration Desk Hours

International Foyer

7:00 am - 8:00 am

Mentoring Breakfast

Rouge

7:00 am - 8:00 am

AAP Council Meeting

State Room, 2nd Level

8:00 am - 9:00 am

APSA Board of Directors Meeting

Embassy Room

8:00 am - 9:00 am

Mentored Poster Session
(Continental Breakfast available)

 

9:00 am - 11:45 am

Plenary Session II: Disruption in Physician Scientist Resident Training

International Ballroom

9:00 am - 9:30 am

Invited Speaker:

Speaker Headshot

Translating Neuroscience: Obstacles and Opportunities
Kafui Dzirasa MD, PhD
Duke University

Kafui Dzirasa completed a PhD in Neurobiology at Duke University. His research interests focus on understanding how changes in the brain produce neurological and mental illness, and his graduate work has led to several distinctions including: the Somjen Award for Most Outstanding Dissertation Thesis, the Ruth K. Broad Biomedical Research Fellowship, the UNCF·Merck Graduate Science Research Fellowship, and the Wakeman Fellowship. Kafui obtained an MD from the Duke University School of Medicine in 2009, and he completed residency training in General Psychiatry in 2016.

Kafui received the Charles Johnson Leadership Award in 2007, and he was recognized as one of Ebony magazine’s 30 Young Leaders of the Future in February 2008. He has also been awarded the International Mental Health Research Organization Rising Star Award, the Sydney Baer Prize for Schizophrenia Research, and his laboratory was featured on CBS 60 Minutes in 2011. In 2016, he was awarded the inaugural Duke Medical Alumni Emerging Leader Award and the Presidential Early Career Award for Scientists and Engineers: The Nation’s highest award for scientists and engineers in the early stages of their independent research careers. In 2017, he was recognized as 40 under 40 in Health by the National Minority Quality Forum, and the Engineering Alumni of the Year from UMBC. He was induced into the American Society for Clinical Investigation in 2019.

Kafui has served as an Associate Scientific Advisor for the journal Science Translational Medicine, a member of the Congressional-mandated Next Generation Research Initiative, and on the NIH Director’s guiding committee for the BRAIN Initiative. He currently serves on the Editorial Advisory Board for TEDMED. Kafui is an Associate Professor at Duke University with appointments in the Departments of Psychiatry and Behavioral Sciences, Neurobiology, Biomedical Engineering, and Neurosurgery. His ultimate goal is to combine his research, medical training, and community experience to improve outcomes for diverse communities suffering from Neurological and Psychiatric illness.

International Ballroom

9:30 am - 10:30 am

Panel: Disruption in Physician Scientist Resident Training

International Ballroom

9:30 am – 9:40 am

Panelist:

Speaker Headshot

National Initiatives Supporting Physician Scientist Careers
Christopher S. Williams, MD, PhD
Vanderbilt University

Dr. Williams is the Associate Dean for Physician-Scientist Education and Training and Professor of Medicine, Gastroenterology, and current director of the Medical Scientist Training Program (MSTP) and associate director of the Harrison Society (PSTP/ABIM Research Pathway) at Vanderbilt University. He is also co-PI of Vanderbilt’s R38-STaRR and Associate Director of the Burroughs Welcome Fund Physician Scientist Institutional Program at Vanderbilt. He was inducted into the ASCI in 2015, four decades after his father. His research program is focused on intestinal injury response/repair programs with the goal of understanding how these epithelial integrity programs are perturbed in the pathogenesis of IBD and more importantly in the progression to malignancy with the overarching goal of identifying novel therapeutic targets or biomarkers in this disease. Also pertinent to the annual meeting, he has been active in the AAMC, ASCI, AAIM, and APSA in promoting physician-scientist training. He recently led the ASCI Working Group on Physician Scientist Training and currently chairs the AAIM Physician Scientist Postgraduate Training Committee and the AAMC Physician Scientist Outreach Committee.

International Ballroom

9:40 am – 9:46 am

Panelist:

Speaker Headshot

Disrupting Residency Training for Coordinated Physician Scientist Development
Sallie R. Permar, MD, PhD
Duke University

Dr. Permar is a physician scientist focusing on the prevention and treatment of neonatal viral infections. She leads a research laboratory investigating immune protection against vertical transmission of neonatal viral pathogens, namely HIV and cytomegalovirus (CMV), using human cohorts and nonhuman primate models. Dr. Permar has made important contributions to the development of vaccines for prevention of vertical HIV transmission, defining both innate and adaptive immune responses that are associated with protection against infant HIV acquisition. Moreover, Dr. Permar is leading the development of HIV vaccine strategies in preclinical maternal/infant nonhuman primate models and translation of this work for clinical vaccine trials in infants. Dr. Permar has also worked to understand the determinants of congenital and perinatal CMV transmission, developing the first nonhuman primate model of congenital CMV infection and designing human cohort studies that have been used to define the immune correlates of protection necessary to guide vaccine development.

Dr. Permar has a PhD in Microbiology/Immunology from Johns Hopkins Bloomberg School of Public Health in Baltimore, an M.D. from Harvard Medical School and completed her clinical training in pediatric infectious diseases at Children’s Hospital in Boston. She has received several prestigious early-stage investigator awards, including the Presidential Early Career Award in Science and Engineering (PECASE) and was inducted into the American Society of Clinical Investigation (ASCI) in 2016 and Fellow of the American Academy of Microbiology (AAM) in 2018. She is an institutional and national leader in physician-scientist training, serving as the Associate Dean of Physician-Scientist Development at Duke University Medical School and was selected by the Association of Medical School Pediatric Department Chairs (AMSPDC) as the next Director of the national Pediatric Scientist Development Program in 2019.

International Ballroom

9:46 am – 9:52 am

Panelist:

Speaker Headshot

Disrupting the Approach to Scientific Education During Residency Training 

Rebecca M. Baron, MD, PhD
Brigham and Women's Hospital

Dr. Baron was born and raised in Chicago, attended Stanford for college, followed by Harvard for Medical School and Brigham and Women’s Hospital for residency and chief residency. She completed Pulmonary and Critical Care Fellowship Training in the Harvard Combined Pulmonary and Critical Care Fellowship Program, followed by a research fellowship in the laboratory of Dr. Mark Perrella. Dr. Baron is a physician scientist whose clinical interests are in critical care and whose research interests span basic and translational mechanisms underlying sepsis and lung injury. She is the Associate Program Director for Scholarship for the Brigham and Women’s Hospital Internal Medicine Residency, where she is the director of the physician scientist pathway and focuses on career development and science educational opportunities for the residents.

International Ballroom

9:52 am – 9:58 am

Panelist:

Speaker Headshot

 
Kafui Dzirasa, MD, PhD
Duke University

Kafui Dzirasa completed a PhD in Neurobiology at Duke University. His research interests focus on understanding how changes in the brain produce neurological and mental illness, and his graduate work has led to several distinctions including: the Somjen Award for Most Outstanding Dissertation Thesis, the Ruth K. Broad Biomedical Research Fellowship, the UNCF·Merck Graduate Science Research Fellowship, and the Wakeman Fellowship. Kafui obtained an MD from the Duke University School of Medicine in 2009, and he completed residency training in General Psychiatry in 2016.

Kafui received the Charles Johnson Leadership Award in 2007, and he was recognized as one of Ebony magazine’s 30 Young Leaders of the Future in February 2008. He has also been awarded the International Mental Health Research Organization Rising Star Award, the Sydney Baer Prize for Schizophrenia Research, and his laboratory was featured on CBS 60 Minutes in 2011. In 2016, he was awarded the inaugural Duke Medical Alumni Emerging Leader Award and the Presidential Early Career Award for Scientists and Engineers: The Nation’s highest award for scientists and engineers in the early stages of their independent research careers. In 2017, he was recognized as 40 under 40 in Health by the National Minority Quality Forum, and the Engineering Alumni of the Year from UMBC. He was induced into the American Society for Clinical Investigation in 2019.

Kafui has served as an Associate Scientific Advisor for the journal Science Translational Medicine, a member of the Congressional-mandated Next Generation Research Initiative, and on the NIH Director’s guiding committee for the BRAIN Initiative. He currently serves on the Editorial Advisory Board for TEDMED. Kafui is an Associate Professor at Duke University with appointments in the Departments of Psychiatry and Behavioral Sciences, Neurobiology, Biomedical Engineering, and Neurosurgery. His ultimate goal is to combine his research, medical training, and community experience to improve outcomes for diverse communities suffering from Neurological and Psychiatric illness.

International Ballroom

10:00 am - 10:30 am

Panel Discussion and Audience Questions

International Ballroom

10:30 am - 10:45 am

Break

 

10:45 am - 11:00 am

APSA trainee oral abstract presentation

International Ballroom

11:00 am - 11:15 am

APSA trainee oral abstract presentation

International Ballroom

11:15 am - 11:45 am

APSA Speaker:

Speaker Headshot

Svati H. Shah, MD, MHS
Duke University

International Ballroom

11:45 am - 1:30 pm

Mentored Poster Session
(lunch available)

Imperial Ballroom

1:30 pm - 3:00 pm

Plenary Session III: Disruptive Technology

International Ballroom

1:30 pm – 2:15 pm

Invited Speakers:

Therapeutic Bacteriophages: From Petri Dish to Patient 

Speaker HeadshotRobert "Chip" T. Schooley, MD
University of California San Diego

Dr. Schooley currently serves as Professor of Medicine, Senior Director of International Initiatives and Interim Faculty Director of Global Education at the University of California San Diego. He completed medical school and an internal medicine residency at Johns Hopkins and infectious disease fellowships at the NIH and Massachusetts General Hospital. He joined the faculty of Harvard Medical School in 1981. His early research efforts were directed at the pathogenesis and therapy of herpes group and retroviral infections.

He became Head of the Division of Infectious Diseases at the University of Colorado in 1990. He led the NIH’s AIDS Clinical Trials Group (ACTG) from 1995 until 2002 during which time the ACTG performed many of the seminal studies that defined modern antiretroviral chemotherapy. He then led the ACTG in its expansion from a domestic US research operation into one with a global reach. He was recruited to the University of California San Diego and served as Head of UCSD’s Infectious Diseases Division until 2017.

Over the past several years, he has become interested in the use of viruses as therapeutic agents – namely the use of bacteriophages to treat multidrug resistant bacterial infections.

Speaker HeadshotGraham F. Hatfull, PhD
University of Pittsburgh

Dr. Hatfull is Professor of Biological Sciences at the University of Pittsburgh. He received his Ph.D. in Molecular Biology from Edinburgh University in 1981 and did postdoctoral work at Yale University with Dr. Nigel Grindley and at the Medical Research Council at Cambridge University, with Fred Sanger and Bart Barrell. He joined the University of Pittsburgh in 1988 and served as Chair of the Department of Biological Sciences from 2003 to 2011. Dr. Hatfull’s research focuses on the molecular genetics of the mycobacteria and their bacteriophages, and their use for educational advancement. Dr. Hatfull has published over 240 peer-reviewed articles, 40 book chapters or reviews, and co-edited four books. He is a fellow of the American Academy of Microbiology, a fellow of the American Association for the Advancement of Science, and a teaching fellow of the National Academy of Science. He has been a Howard Hughes Medical Institute Professor since 2002.

2:15 pm – 2:45 pm

Invited Speaker:

Speaker Headshot

Novel Genomics Perspectives on Cancer Evolution - From Basic Principles to Therapeutic Optimization
Daniel Landau, MD, PhD
Weill Cornell Medical College

Dan Landau, MD, PhD, is physician-scientist who integrates data science innovation with genomic technology development to unravel the basic principles of tumor evolution as a key to cancer cure. He gained his MD from Tel Aviv University and summa cum laude PhD in Cancer Biology from Paris Diderot University. He completed a Medicine residency and fellowship in Hematology and Medical Oncology at Yale University, as well as postdoctoral fellowship at Dana Farber Cancer Institute and the Broad Institute of Harvard and MIT. He now serves as an Assistant Prof. of Medicine at the Meyer Cancer Center (WCM), and member of the WCM Institute of Computational Biomedicine, as well as a Core Member of the NYGC. His studies defined cancer genetic and epigenetic diversity and its contribution to cancer evolution. His work received numerous awards including the Burroughs Wellcome Fund Career Award for Medical Scientists, K01 from the Big Data to Knowledge (BD2K) NIH initiative, SU2C Innovative Research Grant, and the NIH Director’s New Innovator Award.

International Ballroom

2:45 pm - 3:15 pm

Break

 

3:15 pm - 5:30 pm

Session: Disruptive Data Engineering

International Ballroom

3:15 pm – 3:45 pm

Invited Speaker: 

Speaker Headshot

PheWAS: Discovering Gene-disease Associations 

Joshua C. Denny, MD
Vanderbilt University

Josh Denny is a Professor of Biomedical Informatics and Medicine, Director of the Center for Precision Medicine, and Vice President for Personalized Medicine. His research interests include natural language processing, accurate phenotype identification from electronic medical record data, and using the electronic medical record to discover genome‐phenome associations to better understand disease and drug response, including the development of the EMR‐based phenome‐wide association (PheWAS).

He is PI of the Data and Research Center of the All of Us Research Program, which launched nationally in May 2018 and has already enrolled >220k individuals en route to 1 million or more to understand the genetic, environmental, and behavioral factors that influence human health and disease. He is also PI for Vanderbilt sites in the Electronic Medical Records and Genomics (eMERGE) Network, Pharmacogenomics Research Network (PGRN), and the Implementing Genomics Into Practice (IGNITE) Network.

He is a member of the National Academy of Medicine, the American Society for Clinical Investigation, and the American College of Medical Informatics.

International Ballroom

3:45 pm – 4:15 pm

Invited Speaker:

Speaker Headshot

Genetic Data Analytics and Insights From Patients to Uncover New Mechanisms for Vascular Diseases

Dianna Milewicz, MD, PhD
McGovern Medical School

Dianna M. Milewicz, M.D. Ph.D., is the President George H.W. Bush Chair of Cardiovascular Medicine at McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth). She completed her postgraduate training in internal medicine and medical genetics, and forged a career in translational research studies focused on identifying genetic triggers for aortic dissection and other vascular diseases. Her research has identified a large number of genes with highly penetrant rare variants predisposing to vascular diseases, and genetic testing for these genes are widely used for clinical diagnosis. She has sought to rapidly and efficiently translate her research findings into improved clinical care and launched the international Montalcino Aortic Consortium to move to gene-based management for aortic disease patients worldwide. She has received numerous honors and awards for her research, including the Antoine Marfan Award, the Doris Duke Distinguished Clinical Scientist Award, the American Heart Association Merit Award, and the University of Texas Presidential Scholars Award for Excellence in Research, along with induction into ASCI and AAP. Dr. Milewicz been committed to patient advocacy and physician scientist training, and has directed the joint Medical Scientist Training Program for UT Health and MD Anderson Cancer Center for over 15 years.

International Ballroom

4:15 pm – 4:45 pm

AAP Presidential Address:

Speaker HeadshotMary E. Klotman, MD
Duke University

International Ballroom

4:45 pm – 5:15 pm

Kober Medal Presentation

Speaker HeadshotRecipient: Michael J. Welsh, University of Iowa

Speaker HeadshotPresenter: Joseph Zabner, University of Iowa

International Ballroom

5:15 pm – 5:30 pm

AAP Business Meeting

 

5:45 pm - 7:00 pm

APSA Panel: Team-Based Science

Crystak Room

6:30 pm – 9:00 pm

ASCI Food & Science Evening
Featuring Poster Presentations by the ASCI’s 2020 Young Physician-Scientist Award Recipients

Mid America Club

7:00 pm – 9:30 pm

AAP Banquet and New Member Induction Ceremony 
From Bedside to Bench: Renewing a Path for Medically-Trained Scientists

Speaker HeadshotSpeaker: Erin K. O'Shea, PhD
President, Howard Hughes Medical Institute

Erin O’Shea is president of the Howard Hughes Medical Institute (HHMI), a leading research organization that powers basic scientific discovery and education to benefit us all. Since 2016, O’Shea has expanded HHMI’s leadership role in science to include a new focus on the culture of research. A member of the National Academy of Sciences, she heads a research lab at HHMI’s Janelia Research Campus that studies glial cells in the brain. In addition, she serves on the boards of the Albert and Mary Lasker Foundation and Rescuing Biomedical Research and on the scientific advisory board of the Francis Crick Institute. O’Shea holds a PhD from the Massachusetts Institute of Technology.

Imperial Ballroom

7:30 pm – 9:30 pm

APSA Dinner and Founder's Award Presentation

Rouge

9:45 pm – 11:30 pm

Dessert Reception (open to all attendees)

Imperial Lobby

Sunday, April 5

Event

Location

7:30 am - 10:00 am

Registration Desk Hours

International Foyer

7:30 am - 8:30 am   ASCI Institutional Representatives Town Hall

International Ballroom

8:00 am - 12:00 pm APSA Session II

Rouge

8:00 am - 9:30 am

Specialty Interest Breakfast

 

8:30 am - 9:30 am

Society Leadership Wrap Up Meeting

State Room

9:30 am - 10:00 am

APSA Speaker:

Speaker Headshot Jeffrey I. Gordon, MD
Washington University in St Louis

Dr. Katalin Susztak is a physician-scientist at the University of Pennsylvania. Her laboratory is interested in understanding the pathomechanism of chronic kidney disease development. Susztak has made discoveries fundamental towards defining critical genes, cell types and mechanisms of chronic kidney disease. She was instrumental in defining genetic, epigenetic transcriptional changes in diseased human kidneys. She identified novel kidney disease genes and demonstrated the contribution of Notch signaling and metabolic dysregulation in kidney disease development.

Her lab was the first to map the kidney epigenome and catalogue genotype-driven gene-expression variation (eQTL) in human kidneys. Integration of GWAS, eQTL and epigenome data has been essential to prioritize disease-causing genes and variants.

Dr. Susztak generated the first unbiased, comprehensive kidney cell-type atlas using single cell transcriptomics. She identified that specific renal endophenotypes are linked and likely caused by the dysfunction of specific cell types.

Gold Room

10:00 am - 11:00 am

APSA Panel: Fellowship and Specialities

Gold Room

10:00 am - 11:00 am

APSA Panel: Women in Science

 

11:00 am - 12:00 pm

APSA Panel: Policy (Addressing Sex and Gender Health Disparities in Medical Research)

Gold Room

11:00 am - 12:00 pm

APSA Panel: Social Sciences and Humanities (Big Data: Social and Cultural Perspectives)

Embassy Room

12:00 pm - 2:00 pm

Residency Luncheon

International Ballroom

2:00 pm - 4:30 pm

APSA Research Pathway Residency Program Directors Meeting

State Room