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2020 Agenda
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Friday, April 3

Event

Location

8:00 am - 6:30 pm

Registration Desk Hours

International Foyer

8:30 am - 11:00 am

APSA Business Meeting (open to all APSA Members)

Rouge

10:00 am - 12:00 pm Networking Workshop for ASCI's Young Physician-Scientist Awardees  

11:00 am - 1:00 pm

APSA Session I - Disrupting Precision Medicine
Moderator: Eileen Hu

International Ballroom

11:00 am - 11:30 am

APSA Speaker:

Speaker HeadshotRethinking Cancer and Health in Light of the Microbiome
Jennifer Wargo, MD 
MD Anderson Cancer Center

Dr. Wargo’s career commitment has been to advance the understanding and treatment of disease through science. With a joint appointment in Surgical Oncology and Genomic Medicine, she continues her critical research to better understand responses to therapy and develop novel strategies to combat resistance. This includes her groundbreaking recent work elucidating the role of the gut microbiome in shaping responses to immunotherapy in patients with melanoma and a clinical trial underway exploring optimal methods to manipulate the gut microbiome to enhance responses to cancer therapy.

International Ballroom

11:30 am- 12:00 pm

APSA Speaker:

Speaker HeadshotDefining the Genetic, Genomic and Cellular Architecture of Kidney Diseases
Katalin Susztak, MD, PhD  
Perelman School of Medicine, University of Pennsylvania

Dr. Katalin Susztak is a physician-scientist at the University of Pennsylvania. Her laboratory is interested in understanding the pathomechanism of chronic kidney disease development. Susztak has made discoveries fundamental towards defining critical genes, cell types and mechanisms of chronic kidney disease. She was instrumental in defining genetic, epigenetic transcriptional changes in diseased human kidneys. She identified novel kidney disease genes and demonstrated the contribution of Notch signaling and metabolic dysregulation in kidney disease development.

Her lab was the first to map the kidney epigenome and catalogue genotype-driven gene-expression variation (eQTL) in human kidneys. Integration of GWAS, eQTL and epigenome data has been essential to prioritize disease-causing genes and variants.

Dr. Susztak generated the first unbiased, comprehensive kidney cell-type atlas using single cell transcriptomics. She identified that specific renal endophenotypes are linked and likely caused by the dysfunction of specific cell types.

International Ballroom

12:00 pm - 1:00 pm

Break

 

1:00 pm - 3:00 pm

Poster Setup

Imperial Ballroom

1:00 pm - 6:00 pm

Plenary Session I: Disruptive Metabolism in Medicine
Moderators: Donna Martin, Elizabeth McNally, Jose Rodrigues

International Ballroom

1:00 pm – 1:30 pm

Invited Speaker:

Speaker HeadshotHow Mitochondria and Lysosomes Cause Autoimmune Disease
Cornelia Weyand, MD, PhD
Stanford University

Cornelia M. Weyand, M.D., Ph.D. is Professor of Medicine and Director of the Center for Translational Medicine at Stanford University School of Medicine.

Dr. Weyand is leading a research team in translational immunology supported continuously through funding from the National Institute of Health. She has a special interest in tissue-damaging immune responses in rheumatoid arthritis, atherosclerosis and large vessel vasculitis. Dr. Weyand’s research team has defined the role of T cells and dendritic cells in deviating immunity from protective to destructive and over the last decade, she has devoted special emphasis to the remodeling of the immune system with aging, how chronic disease ages the immune system, and how aged immune cells cause inflammation.

She has defined molecular defects underlying the immune abnormalities driving rheumatoid arthritis, implicating defects in mitochondrial DNA repair and intracellular protein trafficking to lysosomal surfaces. Her team has defined metabolic signatures that are linked to pathogenic behavior of T cells and macrophages, representing novel targets for immunomodulatory therapy.

International Ballroom

1:30 pm – 2:00 pm

Invited Speaker:

Speaker HeadshotAssessing Cancer Metabolism in Human Tumors in Vivo
Ralph DeBerardinis, MD, PhD
UT Southwestern

Ralph DeBerardinis studies the role of altered metabolism in pediatric inborn errors of metabolism, cancer and other diseases. He is an Investigator in the Howard Hughes Medical Institute and Professor in the Children’s Research Institute (CRI) at UT Southwestern Medical Center. Dr. DeBerardinis earned a B.S. in Biology from St. Joseph’s University and M.D. and Ph.D. degrees from the University of Pennsylvania. He then trained in Pediatrics, Medical Genetics and Clinical Biochemical Genetics at The Children’s Hospital of Philadelphia before moving to UT Southwestern. Dr. DeBerardinis is Chief of Pediatric Genetics and Metabolism at UT Southwestern, where his clinical team seeks to improve diagnostics and care of children with genetically-defined metabolic disorders. He also directs the CRI’s Genetic and Metabolic Disease Program, which performs basic and translational research to discover new aspects of metabolic disease amenable to clinical intervention. The DeBerardinis laboratory has identified many metabolic pathways that support cancer cell growth and cancer progression. Dr. DeBerardinis received an Outstanding Investigator Award from the National Cancer Institute in 2017 and the O’Donnell Award in Medicine from the Academy of Medicine, Engineering & Science of Texas in 2019.

International Ballroom

2:00 pm- 2:15 pm

ASCI / Seldin~Smith Award Lecture

Speaker Headshot Vijay G. Sankaran, MD, PhD
Dana-Farber Cancer Institute

Recipient, 2019 Seldin~Smith Award for Pioneering Research 

Dr. Sankaran’s laboratory uses human genetic studies to gain insight into normal blood cell production and how this goes awry in human disease. The laboratory has identified over a dozen genes implicated in congenital forms of anemia and other blood disorders. In addition, the laboratory has identified key regulators of fetal and other hemoglobin subtypes in humans. A major ongoing emphasis of the laboratory is to be able to use genomic technologies, including modern sequencing approaches and massively parallel assays, to more comprehensively define both common and rare genetic variation underlying alterations in blood production found in patients with blood disorders and in healthy individuals. The laboratory also has a strong interest in using insight from human genetic studies to develop improved autologous stem cell-based therapies to treat numerous blood disorders and to identify approaches to induce fetal hemoglobin for therapy of the hemoglobin disorders. Dr. Vijay G. Sankaran is an Associate Professor of Pediatrics at Harvard Medical School and an Attending Physician in Hematology/Oncology at Boston Children’s Hospital and the Dana-Farber Cancer Institute. He received a B.A. and M.S. from the University of Pennsylvania in biochemistry, an M.Phil. from the University of Cambridge in biochemistry, and earned his M.D. and Ph.D. degrees from Harvard Medical School. He subsequently did a residency in pediatrics at Boston Children’s Hospital and Boston Medical Center, followed by a fellowship in pediatric hematology/oncology at Boston Children’s Hospital and the Dana-Farber Cancer Institute.

International Ballroom

ASCI and AAP New Member Presentations

International Ballroom

2:15 pm- 2:30 pm

ASCI Featured New Member Presentation:

Speaker Headshot Deidra Candice Crews, MD, ScM
Johns Hopkins Medicine

2020 inductee, ASCI

Dr. Crews is an Associate Professor of Medicine in the Division of Nephrology and Associate Vice Chair for Diversity and Inclusion of the Department of Medicine at Johns Hopkins University School of Medicine. She is a Core Faculty member of the Welch Center for Prevention, Epidemiology and Clinical Research, and is affiliated with the Hopkins Center to Eliminate Cardiovascular Health Disparities and the Hopkins Center on Aging and Health. Dr. Crews’ core area of research addresses disparities in the care and outcomes of chronic kidney disease. She has examined the contribution of social determinants of health, including poverty and access to healthful foods, to disparities in kidney disease. Her work in end-stage renal disease includes studies of the optimal timing and setting of dialysis initiation among vulnerable groups, and patient preparation for the start of renal replacement therapy. Dr. Crews was the inaugural Gilbert S. Omenn Anniversary Fellow of the Institute of Medicine (National Academy of Medicine). She is Chair of the American Society of Nephrology Chronic Kidney Disease Advisory Group and a member of the Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team. She has more than 45 peer-reviewed published manuscripts, and serves on the editorial boards of BMC Nephrology and Advances in Chronic Kidney Disease. Dr. Crews previously served as a member of the Advisory Panel on Addressing Disparities and a member of the Advisory Panel on Healthcare Delivery and Disparities Research from August 2016 to August 2019.

International Ballroom

2:30 pm- 2:45 pm

AAP featured new member presentation:

Speaker HeadshotUnderstanding and Reversing Pancreatic Beta Cell Dysfunction in Diabetes
Maike Sander, MD
University of California, San Diego

Maike Sander is the Director of UC San Diego Pediatric Diabetes Research Center. The major focus of her research is to understand the molecular mechanisms that control the formation and proper function of insulin-producing pancreatic beta cells. Her work combines genetic approaches in mice and human embryonic stem cells with next generation sequencing-based assays. By uncovering fundamental mechanisms of cell fate determination and plasticity in the context of beta cell development, regeneration, and pathogenesis of diabetes, her work aims to develop novel therapeutic strategies for diabetes. Her honors include the Grodsky Award from the Juvenile Diabetes Research Foundation, the Humboldt Research Award, and election to the American Society of Clinical Investigation and German National Academy of Sciences.

International Ballroom

2:45 pm- 3:00 pm

AAP Featured New Member Presentation:

Speaker HeadshotAtopy as a Systems Disease: Translating Molecular Signals to Cures
Kari Nadeau, MD, PhD  
Stanford University

Dr. Kari Nadeau is the Naddisy Foundation Endowed Professor of Medicine and Pediatrics and, Director of the Sean N. Parker Center for Allergy and Asthma Research at Stanford University. She is Section Chief in asthma and allergy in Pulmonary and Critical Care at Stanford. For more than 30 years, she has devoted herself to understanding how environmental and genetic factors affect the risk of developing allergies and asthma, and the molecular mechanisms underlying the diseases. As one of the nation’s foremost experts in adult and pediatric allergy and asthma, her research is laying the groundwork for a variety of potential future therapies to prevent and cure allergies and asthma. She leads a diverse team of specialists—in areas from immunology to chemical engineering—was the first to show that high dimensional immunophenotyping of T cells involved in allergy could be used in therapies for patients. Her research has also shown that blocking antibodies in conjunction with allergen immunotherapy produced desensitization even in patients with up to five food allergens. She has overseen more than 40 clinical trials and enrolled more than 2,000 patients in allergy studies. Her work has changed the lives of many who, for the first time in their lives, are able to control life-threatening food allergies.

International Ballroom

3:00 pm - 3:30 pm Break
3:30 pm - 4:00 pm ASCI / Harrington Prize Lecture
Moderators: Mitchell Lazar, Hannah Turbeville, Lorraine Ware
International Ballroom

4:00 pm - 4:30 pm

APSA Lasker Award Winner Lecture

Speaker Headshot Evolution of Alternative Adaptive Immune Systems
Max D. Cooper, MD
Emory University

Max D. Cooper, M.D., is a Georgia Research Alliance Eminent Scholar, Professor of Pathology and Laboratory Medicine and member of the Vaccine Center at the Emory University School of Medicine. Cooper obtained his medical degree and pediatric residency training at Tulane University Medical School. While at the University of Minnesota from 1963-1967 he worked with Robert Good to establish the dual nature of the immune system. With UAB graduate student Paul Kincade, he discovered antibody class switching by B cells. Dale Bockman and Cooper described the lymphoid follicle-associated epithelial “M” cells in the intestine and their transcytotic function. While on sabbatical at University College London in 1974, he worked with Martin Raff and John Owen to define the fetal liver and bone marrow origin of B cells and pre-B cells. His laboratory currently studies the evolution of adaptive immunity and explores the use of lamprey monoclonal antibodies for diagnosis and therapy of infectious diseases and lymphoid malignancies. Cooper is a former president of the American Association of Immunologists, the Clinical Immunology Society and the Kunkel Society. He is a member of the U.S. National Academy of Sciences, National Academy of Medicine, American Academy of Arts and Sciences, a foreign member of the French Academy of Sciences and the Royal Society of London. Honors include the Society for Experimental Biology and Medicine Founder’s Award (1966), Sandoz Prize in Immunology (1990), American College of Physicians Science Award (1994), American Association of Immunologists (AAI) Lifetime Achievement Award (2000), AAI-Dana Foundation Award in Human Immunology Research (2006), Avery-Landsteiner Prize (2008), Robert Koch Prize (2010), AAI Excellence in Mentoring Award (2012), Japan Prize (2018) and Albert Lasker Basic Medical Research Award (2019).

International Ballroom

4:30 pm - 5:00 pm

ASCI Presidential Address

Speaker Headshot Kimryn Rathmell, MD, PhD
Vanderbilt University

International Ballroom

5:00 pm - 5:30 pm

ASCI/Stanley J. Korsmeyer Award Lecture

Speaker Headshot Judith A. James, MD, PhD
University of Oklahoma Health Sciences Center and the Oklahoma Medical Research Foundation

Dr. James is the recipient of the 2020 Stanley J. Korsmeyer Award from the American Society for Clinical Investigation (ASCI) for her contributions to understanding the mechanisms of systemic autoimmune diseases. Dr. James earned her BS from Oklahoma Baptist University in 1989 and her PhD and MD from the University of Oklahoma Health Sciences Center (OUHSC) in 1993 and 1994, respectively. From 1993 to 1995, she was a postdoctoral fellow at the Oklahoma Medical Research Foundation (OMRF) in the laboratory of John Harley, MD, PhD. At OUHSC, she completed her internship and residency in internal medicine and a fellowship in rheumatology. Dr. James, a native of Pond Creek, Oklahoma, began her affiliation with OMRF as a Sir Alexander Fleming Scholar in 1988. She joined the scientific staff of OMRF in 1994. She is Vice President of Clinical Affairs, OMRF, and Associate Vice Provost for Clinical and Translational Science, OUHSC. She holds the George Lynn Cross Research Professorship and is Professor of Medicine, Professor of Pathology, and Adjunct Professor of Microbiology and Immunology, OUHSC; and is Lou C. Kerr Endowed Chair in Biomedical Research, OMRF. Dr. James has received national and international recognition for her achievements, including the US Presidential Early Career Award for Scientists and Engineers (2000); the Edmund L. Dubois, MD, Memorial Lectureship, Research and Education Foundation of the American College of Rheumatology (2007); the Paul Klemperer, MD, Memorial Lectureship of the American College of Rheumatology (2019), and the Evelyn V. Hess, MD Award from the Lupus Foundation of America (2019). She was elected to the Henry Kunkel Society in 2002 and to the ASCI in 2003. Dr. James served from 2012 to 2015 on the ASCI Council as Secretary-Treasurer Elect and Secretary-Treasurer.

International Ballroom

5:45 pm - 7:00 pm

APSA-Trainee-Specific Business Meeting Focusing on International Training Collaborations

 State

6:00 pm – 7:00 pm

ASCI President's Reception
Celebrating 5 Years of the Seldin~Smith Award

Gold Room

6:15 pm – 9:30 pm

Poster Viewing 

Imperial Ballroom

7:30 pm - 9:45 pm

ASCI Dinner and New Member Induction Ceremony

Speaker Headshot Speaker: William G. Kaelin, Jr., MD
Dana-Farber Cancer Institute

2019 Nobel Laureate  

Dr. Kaelin obtained undergraduate and M.D. degrees from Duke University and completed his internal medicine training at the Johns Hopkins Hospital, where he served as chief medical resident. He was a clinical fellow in medical oncology at the Dana-Farber Cancer Institute and a postdoctoral fellow in the laboratory of David Livingston, during which time he was a McDonnell Scholar. He is currently the Sidney Farber Professor of Medicine in the Department of Medicine at the Dana-Farber Cancer Institute and the Brigham and Women's Hospital, Harvard Medical School. A Nobel laureate, Dr. Kaelin received the 2019 Nobel Prize in Physiology or Medicine. Dr. Kaelin is a member of the American Society for Clinical Investigation, the American College of Physicians, the National Academy of Sciences and the National Academy of Medicine. He recently served on the NCI Board of Scientific Advisors, the AACR Board of Trustees, and the IOM National Cancer Policy Board. He has received numerous awards including the MSKCC Paul Marks Prize, the AACR Richard and Hinda Rosenthal Prize, a Doris Duke Distinguished Clinical Scientist Award, the Canada International Gairdner International Award, the ASCI Stanley J. Korsmeyer Award, the Scientific Grand Prix of the Foundation Lefoulon-Delalande and the Institute of France, the Albert Lasker Prize, the Helis Award, and the Massry Prize.

Rouge

9:00 pm – 12:00 am

APSA Welcome Reception (all attendees welcome)

Mid-America Club

Saturday, April 4

Event

Location

7:00 am - 6:30 pm

Registration Desk Hours

International Foyer

7:00 am - 8:00 am

Mentoring Breakfast

Rouge

7:00 am - 8:00 am

AAP Council Meeting

State Room, 2nd Level

8:00 am - 9:00 am

APSA Board of Directors Meeting

Embassy Room

8:00 am - 9:00 am

Mentored Poster Session
(Continental Breakfast available)

 

9:00 am - 11:45 am

Plenary Session II: Disruption in the Physician Scientist Career Pathway
Moderators: Abhik Banerjee, Mary Klotman, Kimryn Rathmell

International Ballroom

9:00 am - 9:30 am

Invited Speaker:

Speaker Headshot

Translating Neuroscience: Obstacles and Opportunities
Kafui Dzirasa MD, PhD
Duke University

Kafui Dzirasa completed a PhD in Neurobiology at Duke University. His research interests focus on understanding how changes in the brain produce neurological and mental illness, and his graduate work has led to several distinctions including: the Somjen Award for Most Outstanding Dissertation Thesis, the Ruth K. Broad Biomedical Research Fellowship, the UNCF·Merck Graduate Science Research Fellowship, and the Wakeman Fellowship. Kafui obtained an MD from the Duke University School of Medicine in 2009, and he completed residency training in General Psychiatry in 2016.

Kafui received the Charles Johnson Leadership Award in 2007, and he was recognized as one of Ebony magazine’s 30 Young Leaders of the Future in February 2008. He has also been awarded the International Mental Health Research Organization Rising Star Award, the Sydney Baer Prize for Schizophrenia Research, and his laboratory was featured on CBS 60 Minutes in 2011. In 2016, he was awarded the inaugural Duke Medical Alumni Emerging Leader Award and the Presidential Early Career Award for Scientists and Engineers: The Nation’s highest award for scientists and engineers in the early stages of their independent research careers. In 2017, he was recognized as 40 under 40 in Health by the National Minority Quality Forum, and the Engineering Alumni of the Year from UMBC. He was induced into the American Society for Clinical Investigation in 2019.

Kafui has served as an Associate Scientific Advisor for the journal Science Translational Medicine, a member of the Congressional-mandated Next Generation Research Initiative, and on the NIH Director’s guiding committee for the BRAIN Initiative. He currently serves on the Editorial Advisory Board for TEDMED. Kafui is an Associate Professor at Duke University with appointments in the Departments of Psychiatry and Behavioral Sciences, Neurobiology, Biomedical Engineering, and Neurosurgery. His ultimate goal is to combine his research, medical training, and community experience to improve outcomes for diverse communities suffering from Neurological and Psychiatric illness.

International Ballroom

9:30 am - 10:30 am

Panel: Disruption in Physician Scientist Resident Training

International Ballroom

9:30 am – 9:40 am

Panelist:

Speaker Headshot

National Initiatives Supporting Physician Scientist Careers
Christopher S. Williams, MD, PhD
Vanderbilt University

Dr. Williams is the Associate Dean for Physician-Scientist Education and Training and Professor of Medicine, Gastroenterology, and current director of the Medical Scientist Training Program (MSTP) and associate director of the Harrison Society (PSTP/ABIM Research Pathway) at Vanderbilt University. He is also co-PI of Vanderbilt’s R38-STaRR and Associate Director of the Burroughs Welcome Fund Physician Scientist Institutional Program at Vanderbilt. He was inducted into the ASCI in 2015, four decades after his father. His research program is focused on intestinal injury response/repair programs with the goal of understanding how these epithelial integrity programs are perturbed in the pathogenesis of IBD and more importantly in the progression to malignancy with the overarching goal of identifying novel therapeutic targets or biomarkers in this disease. Also pertinent to the annual meeting, he has been active in the AAMC, ASCI, AAIM, and APSA in promoting physician-scientist training. He recently led the ASCI Working Group on Physician Scientist Training and currently chairs the AAIM Physician Scientist Postgraduate Training Committee and the AAMC Physician Scientist Outreach Committee.

International Ballroom

9:40 am – 9:46 am

Panelist:

Speaker Headshot

Disrupting Residency Training for Coordinated Physician Scientist Development
Sallie R. Permar, MD, PhD
Duke University

Dr. Permar is a physician scientist focusing on the prevention and treatment of neonatal viral infections. She leads a research laboratory investigating immune protection against vertical transmission of neonatal viral pathogens, namely HIV and cytomegalovirus (CMV), using human cohorts and nonhuman primate models. Dr. Permar has made important contributions to the development of vaccines for prevention of vertical HIV transmission, defining both innate and adaptive immune responses that are associated with protection against infant HIV acquisition. Moreover, Dr. Permar is leading the development of HIV vaccine strategies in preclinical maternal/infant nonhuman primate models and translation of this work for clinical vaccine trials in infants. Dr. Permar has also worked to understand the determinants of congenital and perinatal CMV transmission, developing the first nonhuman primate model of congenital CMV infection and designing human cohort studies that have been used to define the immune correlates of protection necessary to guide vaccine development.

Dr. Permar has a PhD in Microbiology/Immunology from Johns Hopkins Bloomberg School of Public Health in Baltimore, an M.D. from Harvard Medical School and completed her clinical training in pediatric infectious diseases at Children’s Hospital in Boston. She has received several prestigious early-stage investigator awards, including the Presidential Early Career Award in Science and Engineering (PECASE) and was inducted into the American Society of Clinical Investigation (ASCI) in 2016 and Fellow of the American Academy of Microbiology (AAM) in 2018. She is an institutional and national leader in physician-scientist training, serving as the Associate Dean of Physician-Scientist Development at Duke University Medical School and was selected by the Association of Medical School Pediatric Department Chairs (AMSPDC) as the next Director of the national Pediatric Scientist Development Program in 2019.

International Ballroom

9:46 am – 9:52 am

Panelist:

Speaker Headshot

Disrupting the Approach to Scientific Education During Residency Training 

Rebecca M. Baron, MD, PhD
Brigham and Women's Hospital

Dr. Baron was born and raised in Chicago, attended Stanford for college, followed by Harvard for Medical School and Brigham and Women’s Hospital for residency and chief residency. She completed Pulmonary and Critical Care Fellowship Training in the Harvard Combined Pulmonary and Critical Care Fellowship Program, followed by a research fellowship in the laboratory of Dr. Mark Perrella. Dr. Baron is a physician scientist whose clinical interests are in critical care and whose research interests span basic and translational mechanisms underlying sepsis and lung injury. She is the Associate Program Director for Scholarship for the Brigham and Women’s Hospital Internal Medicine Residency, where she is the director of the physician scientist pathway and focuses on career development and science educational opportunities for the residents.

International Ballroom

9:52 am - 10:30 am

Panel Discussion and Audience Questions

International Ballroom

10:30 am - 10:45 am

Break

 

10:45 am - 11:45 am

Plenary Session III: Disruption in Modern Medical Concepts
Moderators: Hossein Ardehali Jeff Chen and Paul Noble

International Ballroom

APSA Trainee Oral Abstract Presentations

International Ballroom

10:45 am - 11:00 am

APSA Speaker:

Speaker HeadshotEndothelial IQGAP1, Calmodulin, and CaMKIIδ Regulate Leukocyte Transendothelial Migration
Prarthana Dalal  
Northwestern University Feinberg School of Medicine

Prarthana Dalal is a MD/PhD student at the Northwestern University Feinberg School of Medicine. Prarthana is interested in vascular biology and immunology and her research focuses on mechanisms of inflammation. Specifically, she has been studying endothelial cell calcium signaling as it relates to leukocyte transendothelial migration and has received awards for her work from the American Society for Investigative Pathology and the Society for Leukocyte Biology. She is currently completing her PhD in the laboratory of William A. Muller, MD PhD. She received her bachelor’s degree in biological sciences from Northwestern University as part of the Honors Program in Medical Education and subsequently joined the Medical Scientist Training Program.

International Ballroom

11:00 am - 11:15 am

APSA Speaker:

Speaker HeadshotUnraveling Antigen Presentation in Central Nervous System Anti-tumor Immunity
Jay Bowman-Kirigin  
Washington University School of Medicine

During MD/PhD training, I became fascinated by the human immune system, in particular, how the immune system recognizes and interacts with cancer. I was captivated by the premise that the body can recognize and eradicate cells that have gone astray and turned malignant. My thesis project explores how antigen presentation and lymphatic drainage works for brain tumors. The hope is that developing a better understanding of this process could potentially elucidate more effective treatment strategies. I aspire to have a career where I can apply information I learn from lab to patients I see in clinic, and vice versa. My hope is that this interplay between lab and clinic will allow me to more effectively aim scientific inquiry to solve relevant scientific problems and to ultimately improve disease outcomes.

International Ballroom

11:15 am - 11:45 am

APSA Speaker:

Speaker HeadshotMetabolic Pathways in Obesity and Heart Failure: Form and Function
Svati H. Shah, MD, MHS
Duke University

Dr. Svati Shah is a physician scientist and Associate Dean of Genomics, Director of Precision Genomics Collaboratory, Vice-Chief of Translational Research in the Division of Cardiology, Department of Medicine, and a faculty member and Co-Director of Translational Research in the Duke Molecular Physiology Institute (DMPI) and Duke Clinical Research Institute (DCRI). Her research focus is on metabolic and genetic pathways of cardiometabolic diseases, integrating diverse genomic, metabolomic and proteomic techniques for identification of novel mechanisms of disease and biomarkers. Her multi-disciplinary molecular epidemiology lab within the DMPI has quantitative and molecular components and leverages several large cardiovascular biorepositories on which she is PI or co-I to perform discovery studies using omics technologies, with subsequent functional validation for mechanistic insight.

Dr. Shah collaborates closely with the DCRI for biomarker discovery in biospecimens from clinical trials and she is the Duke PI for the Verily Project Baseline study. She has partnered with the Duke Global Health Institute (DHGI) to identify disease biomarkers in global populations through a study of metabolic and genomic biomarkers of type II DM and CAD in Gurgaon, India. Dr. Shah is also Director of the Duke Adult Cardiovascular Genetics Clinic where she cares for patients and their families who have, or are at risk of, cardiovascular genetic disorders. Her training includes receiving a M.H.S. in epidemiology from Johns Hopkins School of Public Health, a Master’s degree in Medical Genomics from Duke University, and completing a research fellowship in genetic epidemiology at the Duke Center for Human Genetics.

International Ballroom

11:45 am - 1:30 pm

Mentored Poster Session
(lunch available)

Imperial Ballroom

1:30 pm - 3:00 pm

Plenary Session IV: Disruptive Technology
Moderators: John Carethers, Audra Iness, Kieren Marr

International Ballroom

1:30 pm – 2:15 pm

Invited Speakers:

Therapeutic Bacteriophages: From Petri Dish to Patient 

Speaker HeadshotRobert "Chip" T. Schooley, MD
University of California San Diego

Dr. Schooley currently serves as Professor of Medicine, Senior Director of International Initiatives and Interim Faculty Director of Global Education at the University of California San Diego. He completed medical school and an internal medicine residency at Johns Hopkins and infectious disease fellowships at the NIH and Massachusetts General Hospital. He joined the faculty of Harvard Medical School in 1981. His early research efforts were directed at the pathogenesis and therapy of herpes group and retroviral infections.

He became Head of the Division of Infectious Diseases at the University of Colorado in 1990. He led the NIH’s AIDS Clinical Trials Group (ACTG) from 1995 until 2002 during which time the ACTG performed many of the seminal studies that defined modern antiretroviral chemotherapy. He then led the ACTG in its expansion from a domestic US research operation into one with a global reach. He was recruited to the University of California San Diego and served as Head of UCSD’s Infectious Diseases Division until 2017.

Over the past several years, he has become interested in the use of viruses as therapeutic agents – namely the use of bacteriophages to treat multidrug resistant bacterial infections.

Speaker HeadshotGraham F. Hatfull, PhD
University of Pittsburgh

Dr. Hatfull is Professor of Biological Sciences at the University of Pittsburgh. He received his Ph.D. in Molecular Biology from Edinburgh University in 1981 and did postdoctoral work at Yale University with Dr. Nigel Grindley and at the Medical Research Council at Cambridge University, with Fred Sanger and Bart Barrell. He joined the University of Pittsburgh in 1988 and served as Chair of the Department of Biological Sciences from 2003 to 2011. Dr. Hatfull’s research focuses on the molecular genetics of the mycobacteria and their bacteriophages, and their use for educational advancement. Dr. Hatfull has published over 240 peer-reviewed articles, 40 book chapters or reviews, and co-edited four books. He is a fellow of the American Academy of Microbiology, a fellow of the American Association for the Advancement of Science, and a teaching fellow of the National Academy of Science. He has been a Howard Hughes Medical Institute Professor since 2002.

International Ballroom

2:15 pm – 2:45 pm

Invited Speaker:

Speaker Headshot

Novel Genomics Perspectives on Cancer Evolution - From Basic Principles to Therapeutic Optimization
Daniel Landau, MD, PhD
Weill Cornell Medical College

Dan Landau, MD, PhD, is physician-scientist who integrates data science innovation with genomic technology development to unravel the basic principles of tumor evolution as a key to cancer cure. He gained his MD from Tel Aviv University and summa cum laude PhD in Cancer Biology from Paris Diderot University. He completed a Medicine residency and fellowship in Hematology and Medical Oncology at Yale University, as well as postdoctoral fellowship at Dana Farber Cancer Institute and the Broad Institute of Harvard and MIT. He now serves as an Assistant Prof. of Medicine at the Meyer Cancer Center (WCM), and member of the WCM Institute of Computational Biomedicine, as well as a Core Member of the NYGC. His studies defined cancer genetic and epigenetic diversity and its contribution to cancer evolution. His work received numerous awards including the Burroughs Wellcome Fund Career Award for Medical Scientists, K01 from the Big Data to Knowledge (BD2K) NIH initiative, SU2C Innovative Research Grant, and the NIH Director’s New Innovator Award.

International Ballroom

2:45 pm - 3:15 pm

Break

 

3:15 pm - 5:30 pm

Plenary Session V: Disruptive Data Engineering
Moderators: David Ginsburg Sarah Groover, Sohail Tavazoie

International Ballroom

3:15 pm – 3:45 pm

Invited Speaker: 

Speaker Headshot

PheWAS: Discovering Gene-disease Associations 

Joshua C. Denny, MD
National Institutes of Health

Dr. Josh Denny is the Chief Executive Officer of the National Institutes of Health’s All of Us Research Program. He has been involved in All of Us from its inception, first as a member of the Advisory Committee to the (NIH) Director Precision Medicine Initiative Working Group, which developed the program’s initial scientific blueprint. He led the program’s initial prototyping project and served as the principal investigator for the All of Us Data and Research Center.

As a physician scientist, Josh is deeply committed to improving patient care through the advancement of precision medicine. Before joining the NIH, Josh was a Professor of Biomedical Informatics and Medicine, Director of the Center for Precision Medicine, and Vice President for Personalized Medicine at Vanderbilt University Medical Center. In his roles at VUMC, he was both a practicing internist and a researcher. His research interests include use of electronic records to better understand disease and drug response. He also led efforts implementing precision medicine to improve patient outcomes. Josh was a leader in the development of phenome‐wide association studies (PheWAS) and phenotype risk scores.

He served as PI for Vanderbilt sites in the Electronic Medical Records and Genomics (eMERGE) Network, Pharmacogenomics Research Network (PGRN), and the Implementing Genomics Into Practice (IGNITE) Network.

He is an elected member of the National Academy of Medicine, the American Society for Clinical Investigation, and the American College of Medical Informatics.

International Ballroom

3:45 pm – 4:15 pm

Invited Speaker:

Speaker HeadshotGenetic Data Analytics and Insights From Patients to Uncover New Mechanisms for Vascular Diseases
Dianna Milewicz, MD, PhD
McGovern Medical School

Dianna M. Milewicz, M.D. Ph.D., is the President George H.W. Bush Chair of Cardiovascular Medicine at McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth). She completed her postgraduate training in internal medicine and medical genetics, and forged a career in translational research studies focused on identifying genetic triggers for aortic dissection and other vascular diseases. Her research has identified a large number of genes with highly penetrant rare variants predisposing to vascular diseases, and genetic testing for these genes are widely used for clinical diagnosis. She has sought to rapidly and efficiently translate her research findings into improved clinical care and launched the international Montalcino Aortic Consortium to move to gene-based management for aortic disease patients worldwide. She has received numerous honors and awards for her research, including the Antoine Marfan Award, the Doris Duke Distinguished Clinical Scientist Award, the American Heart Association Merit Award, and the University of Texas Presidential Scholars Award for Excellence in Research, along with induction into ASCI and AAP. Dr. Milewicz been committed to patient advocacy and physician scientist training, and has directed the joint Medical Scientist Training Program for UT Health and MD Anderson Cancer Center for over 15 years.

International Ballroom

4:15 pm – 4:45 pm

AAP Presidential Address:

Speaker HeadshotThe Changing Face of the AAP
Mary E. Klotman, MD
Duke University

Mary E. Klotman, MD, was chair of the Department of Medicine at Duke University March 1, 2010 through July 1, 2017. On July 1 she became dean of the Duke School of Medicine and Vice Chancellor for Health Affairs, Duke University.

Klotman earned her undergraduate (zoology) and medical degrees from Duke, and then completed her internal medicine residency and a fellowship in Infectious Diseases in the Department of Medicine at Duke. She became assistant professor of medicine at Duke before moving to the National Institutes of Health, where she was a member of the Public Health Service and trained and worked in the Laboratory of Tumor Cell Biology under the direction of Robert C. Gallo, MD.

In 1994, Klotman joined the faculty at Mount Sinai School of Medicine in New York City, where she was a tenured professor of medicine and microbiology and associate professor of gene and cell medicine; she held the Irene and Dr. Arthur M. Fishberg Chair in Infectious Diseases. She also served as chief of the Division of Infectious Diseases for 13 years and as co-director of Mount Sinai’s Global Health and Emerging Pathogens Institute, a program designed to translate basic science discoveries into clinical therapeutics for newly emerging and re-emerging infectious diseases. She returned to Duke in March 2010 to become chair of the Department of Medicine.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection. Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney diseaseHer research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV. Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. She has mentored a number of pre- and post-doctoral students in laboratory-based research in infectious diseases.

Klotman is editor of Annual Reviews of Medicine. She was elected to membership in the Academy of Medicine in 2014, and she has served as councilor and now is president of Association of American Physicians and past president of the Association of Professors of Medicine. She is a former president of the Duke Medical Alumni Association, and she received a Duke School of Medicine Distinguished Alumni Award in 2015.

International Ballroom

4:45 pm – 5:15 pm

Kober Medal Presentation

Speaker HeadshotRecipient: Michael J. Welsh, University of Iowa

Dr. Michael Welsh obtained an MD and completed internal medicine residency at the University of Iowa. He trained in pulmonary medicine and research at the University of California, San Francisco and University of Texas, Houston. He then joined the University of Iowa where he is Professor Internal Medicine and Molecular Physiology and Biophysics. He directs the Cystic Fibrosis Research Center and Pappajohn Biomedical Institute. He is an Investigator of the Howard Hughes Medical Institute. His clinical activities focused on pulmonary diseases. Dr. Welsh served as president of the American Society for Clinical Investigation and the Association of American Physicians. He was elected to the National Academy of Medicine, American Academy of Arts and Sciences, and National Academy of Sciences. He has received many awards for his work, including the Distinguished Mentor Award Carver College of Medicine, Walter Cannon Award American Physiological Society, Steven Beering Award, and Warren Alpert Foundation Prize.

Speaker HeadshotPresenter: Joseph Zabner, University of Iowa

Dr. Zabner has a long-standing record both in the conduct of clinical/translational research projects and in the translation of basic research into innovative high-risk/high-reward clinical projects.

He is the Vice Chair of Internal Medicine for Translational Research and the Chief of Pulmonary, Critical Care and Occupational Medicine. He has served as Associate Director and Member of the Cystic Fibrosis Research and Development Program and the Gene Therapy Center at The University of Iowa. As Professor of Medicine, Pulmonary and Critical Care, Dr. Zabner leads successful, translational, as well as basic research programs in cystic fibrosis, ventilator-associated pneumonia, and bacterial pathogenesis.

He was a pioneer in gene therapy for cystic fibrosis and led the first gene therapy trial using recombinant adenoviruses. The NIH has funded Dr. Zabner since 1995. Dr. Zabner has published clinical research in high-profile journals and is the holder of several patents in biomedical research. He is frequently invited to present his studies at national and international conferences, and he served as the Chair of the Respiratory Track Gene Therapy Scientific Committee, and has served as a Reviewer for the Lung Cell and Molecular Immunology Study Section.

International Ballroom

5:15 pm – 5:30 pm

AAP Business Meeting

 

5:30 pm – 7:00 pm

APSA PSTP Directors Panel (Medicine, Peds, Psych) and (Medicine, Neurology, Surgery) Parallel Sessions

 

5:30 pm – 7:00 pm

APSA Resident, Fellow, and Junior Faculty Session I:
How to Support and Retain Early Career Physician-Scientists

 

5:45 pm - 7:00 pm

APSA Panel: Team-Based Science

Crystak Room

6:30 pm – 9:00 pm

ASCI Food & Science Evening
Featuring Poster Presentations by the ASCI’s 2020 Young Physician-Scientist Award Recipients

Mid America Club

7:00 pm – 9:30 pm

AAP Banquet and New Member Induction Ceremony 

Speaker HeadshotFrom Bedside to Bench: Renewing a Path for Medically-Trained Scientists
Speaker: Erin K. O'Shea, PhD
President, Howard Hughes Medical Institute

Erin O’Shea is president of the Howard Hughes Medical Institute (HHMI), a leading research organization that powers basic scientific discovery and education to benefit us all. Since 2016, O’Shea has expanded HHMI’s leadership role in science to include a new focus on the culture of research. A member of the National Academy of Sciences, she heads a research lab at HHMI’s Janelia Research Campus that studies glial cells in the brain. In addition, she serves on the boards of the Albert and Mary Lasker Foundation and Rescuing Biomedical Research and on the scientific advisory board of the Francis Crick Institute. O’Shea holds a PhD from the Massachusetts Institute of Technology.

Imperial Ballroom

7:00 pm – 9:00 pm

APSA Dinner and Founder's Award Presentation

Speaker HeadshotStem Cells and Genomics for Precision Medicine
Joseph C. Wu, MD, PhD
Stanford University School of Medicine

Joseph C. Wu, MD, PhD is Director of Stanford Cardiovascular Institute and Simon H. Stertzer, MD, Professor of Medicine and Radiology at the Stanford School of Medicine. Dr. Wu received his MD from Yale University. He trained in internal medicine and cardiology at UCLA followed by a PhD in Molecular & Medical Pharmacology.

His lab works on biological mechanisms of patient-specific and disease-specific induced pluripotent stem cells (iPSCs). The main goals are to (i) understand basic cardiovascular disease mechanisms, (ii) accelerate drug discovery and screening, (iii) develop “clinical trial in a dish” concept, and (iv) implement precision cardiovascular medicine for prevention and treatment of patients.

Dr. Wu has received National Institutes of Health (NIH) Director’s New Innovator Award, NIH Roadmap Transformative Award, American Heart Association (AHA) Innovative Research Award, Presidential Early Career Award for Scientists and Engineers given out by President Obama, AHA Established Investigator Award, Burroughs Wellcome Foundation Innovation in Regulatory Science Award, AHA Merit Award, and AHA Distinguished Scientist Award.

Dr. Wu serves on the FDA Cellular, Tissue, and Gene Therapies Advisory Committee, Scientific Advisory Board for the Keystone Symposia, and AHA National Board of Directors. He is also Chair of the AHA National Research Committee.

Dr. Wu is an elected member of American Society of Clinical Investigators (ASCI), Association of University Cardiologists (AUC), American Institute for Medical and Biological Engineering (AIMBE), American Association for the Advancement of Science (AAAS), American Association of Physicians (AAP), and National Academy of Medicine (NAM).

Rouge

9:45 pm – 11:30 pm

Dessert Reception (open to all attendees)

Imperial Lobby

Sunday, April 5

Event

Location

7:30 am - 8:30 am   ASCI Institutional Representatives Town Hall

International Ballroom

8:00 am - 12:00 pm APSA Session II
Moderator: Lillian Zhang

Rouge

8:00 am - 9:00 am

APSA Board of Directors Meeting

 

8:00 am - 9:30 am

Specialty Interest Breakfast

 

8:30 am - 9:30 am

Society Leadership Wrap Up Meeting

State Room

9:30 am - 10:00 am

APSA Speaker:

Speaker HeadshotA Shared Journey Developing Microbiota-directed Therapeutics for Childhood Undernutrition

Jeffrey I. Gordon, MD
Washington University in St Louis

Jeffrey Gordon is the Dr. Robert J. Glaser Distinguished University Professor at Washington University in St. Louis. He received his A.B. from Oberlin College and his M.D. from the University of Chicago. After completing his clinical training in internal medicine and gastroenterology, and doing a post-doctoral fellowship at the NIH, he joined the faculty at Washington University where he has spent his entire career; first as a member of the Departments of Medicine and Biological Chemistry, then as Head of the Department of Molecular Biology and Pharmacology, and for the past decade as founding Director of the University’s interdepartmental Center for Genome Sciences and Systems Biology. Members of his lab have developed gnotobiotic animal models, and new experimental and computational approaches to characterize the assembly, dynamic operations, functional properties, and biological effects of human gut microbial communities. He has combined these models with human studies involving twins as well as members of birth cohorts living in low-, middle- and high-income countries. His group is focused on addressing the global health challenges of obesity and childhood undernutrition through new understanding of the interactions between diets and the gut microbiome and through new ways of promoting healthy development of the gut microbial community during the first several years of postnatal life. To date, he has been the research mentor to 137 PhD and MD/PhD students and post-doctoral fellows. He is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, the National Academy of Medicine, and the American Philosophical Society.

 

10:00 am - 11:00 am

APSA Panel: Policy Panel

State Room

10:00 am - 11:00 am

APSA Panel: Fellowship and Specialties Panel

Gold Room

10:00 am - 11:00 am

APSA Resident, Fellow, and Junior Faculty Session II

Speaker HeadshotIndividual Opportunity Plan

Robert Milner, PhD
University of Massachusetts Medical School 

 

11:00 am - 12:00 pm

APSA Panel: APSA Do’s and Don’ts of MSTP Admissions

State Room

11:00 am - 12:00 pm

APSA Panel: Research!America Workshop

 

12:00 pm - 2:00 pm

Residency Luncheon

 

10:00 am - 12:30 pm

APSA Research Pathway Residency Program Directors Meeting