Dr. Noch’s research focuses on the molecular mechanisms of endogenous tumor-associated necrosis in glioblastoma as well as the regulation of glucose metabolism using targeted therapies and dietary strategies to treat glioblastoma. Within this research program, he uses patient-derived models of glioblastoma to better recapitulate the human disease state and employs a wide variety of available technologies and core facilities within the tri-institutional community. He hopes to improve not only patient outcomes and survival but also overall well-being during treatment, particularly with respect to tumor necrosis that can be a devastating aspect of this tumor type and a major adverse effect of current treatment.