Luigi D. Notarangelo is the Chief of the Laboratory of Clinical Immunology and Microbiology at NIAID, NIH. After completing residency in Pediatrics and fellowships in Allergy/Immunology and Human Genetics in Italy, in 1996 he was appointed as Professor in Pediatrics at the University of Brescia (Italy). In 2006, he was recruited at Boston Children’s Hospital as Professor of Pediatrics and Pathology at Harvard Medical School. In 2016, he moved to the NIH. He has authored more than 500 original articles, mostly on the molecular and cellular bases and treatment of inborn errors of immunity. He has identified several gene defects responsible for severe forms of congenital immunodeficiency. In 2019, he has been elected to the National Academy of Medicine.